THE TREATMENT WITH TRANILAST, A MAST CELL BLOCKER, FOR IDIOPATHIC OLIGOZOOSPERMIA
نویسندگان
چکیده
منابع مشابه
Appearance of spermatozoon after administration of mast cell blocker to a patient with azoospermia.
Since a close relationship has been suggested to exist between testicular disfunction and the increased mast cells in the testis, we used a mast cell blocker for the treatment of patients with idiopathic infestility. An infertile male with idiopathic azoospermia was treated with administration of a mast cell blocker, tranilast for one year. The patient was found to have sperm within his ejacula...
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1 Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich Alexander University ErlangenNuremberg, Erlangen, Germany, 2 Medical Clinic II, Waldkrankenhaus, Erlangen, Germany, 3 Medical Clinic III for Rheumatology and Immunology, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, 4 Institute of Pathology, Friedrich...
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Background: Surgery is considered the most common choice for the treatment of male infertility with clinical varicocele. Increased numbers of mast cells (MCs) have been associated with different types of infertility, including varicocele. Despite there being different reports on improved fertility following administration of MC blockers, there is no report on the effect of a MC blocker on varic...
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BACKGROUND Anti-allergic drugs, such as tranilast and ketotifen, inhibit the release of chemokines from mast cells. However, we know little about their direct effects on the exocytotic process of mast cells. Since exocytosis in mast cells can be monitored electrophysiologically by changes in the whole-cell membrane capacitance (Cm), the absence of such changes by these drugs indicates their mas...
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ژورنال
عنوان ژورنال: Archives of Andrology
سال: 2001
ISSN: 0148-5016
DOI: 10.1080/014850101316901307